In some cases, peripheral IV placement can be quite challenging even for experienced clinicians despite the use of common helpful techniques, such as the use of heat or a tourniquet while the extremity dangles, rubbing the skin over the vein, or illumination devices. Particularly, peripheral IV placement may be challenging in obese patients, edematous or hypovolemic patients, patients with vein-debilitating diseases (e.g. sickle cell disease, cancer) and those undergone repeated venipunctures. These patients often have to undergo multiple insertion attempts and may end up with a central line. However, ultrasound-guided peripheral IV placement can be adopted in many care settings, including emergency departments.