Multidrug-resistant tuberculosis in India: looking back, thinking ahead

Authors: Fojo AT & Dowdy DW

With an estimated 480 000 new cases developing every year, multidrug-resistant tuberculosis is one of the greatest public health challenges worldwide. Multidrug-resistant tuberculosis is much more common in patients who have previously been treated for tuberculosis, and public health efforts have typically focused on high-quality treatment of drug-susceptible tuberculosis to prevent acquisition of resistance while on therapy. However, a substantial proportion of patients with multidrug-resistant tuberculosis might have transmitted drug resistance (ie, present before treatment begins), and drug resistance is therefore often the cause of treatment failure, not the result.

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